The following evidence-based papers present research into various facets of Lyme disease, and are organized into three categories to expedite comprehension:

Treatment Guidelines

Cameron DJ, Johnson LB, Maloney EL. Evidence Assessments and Guideline Recommendations in Lyme Disease: The Clinical Management of Known Tick Bites, Erythema Migrans Rashes and Persistent Disease. Expert Rev Anti Infect There. 2014 Sep;12(9):1103-1135. don:10.1586/14787210.2014.940900

Wormser GP, Dattwyler RJ, Shapiro ED, et al. The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2006 Nov 1;43(9):1089-1134.

Centers for Disease Control and Prevention (CDC). Lyme Disease (Borrelia burgdorferi) 2017 Case Definition. Council of State and Territorial Epidemiologists (CSTE) Position Statement(s)

Diagnosis/Treatment

Cameron DJ. Consequences of treatment delay in Lyme disease. J Eval Clin Pract. 2007 Jun;13(3):470-2.

Maloney EL. The management of Ixodes scapularis bites in the upper midwest. WMJ 2011 Apr;110(2):78-81.

Maloney EL. The need for clinical judgment in the diagnosis and treatment of Lyme disease. J AM Physicians Surgeons. 2009;14(3):82-89

Accuracy of Clinician Suspicion of Lyme Disease in the Emergency Department

Nigrovic LE, Bennett JE, Balamuth F, Levas MN, Chenard RL, Maulden AB, Garro AC; for Pedi Lyme Net.

Pediatrics, online first 2017 Nov 24. pii: e20171975.

Steere AC, Strle F, Wormser GP, et al. Lyme borreliosis. Nature Reviews Disease Primers. 2016 Dec 15;2:16090

Persistent Infection

Cameron DJ. Proof That Chronic Lyme Disease Exists. Interdisciplinary Perspectives on Infectious Diseases, vol. 2010 Article ID 876450, 4 pages, 2010. doi:10.1155/2010/876450

Crowder LA, Yedlin VA, Weinstein ER, Kortte KB, Aucott JN. Lyme disease and post-treatment Lyme disease syndrome: the neglected disease in our own backyard. Public Health. 2014;128(9):784–791.

Feng J, Wang T, Shi W, et al. Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library. Emerging Microbes & Infections. 02 July 2014;3:e49. doi:10.1038/emi.2014.53.

Feng J, Shi W, Zhang S, Zhang Y. Persister mechanisms in Borrelia burgdorferi: implications for improved intervention. Emerging Microbes & Infections. 19 August 2015;4:e51. doi:10.1038/emi.2015.51.

Johnson L, Wilcox S, Mankoff J, Stricker RB. Severity of chronic Lyme disease compared to other chronic conditions: a quality of life survey. PeerJ. 2014 Mar 27;2:e322. doi: 10.7717/peerj.322.

Lobraico J, Butler A, Petrini J, Ahmadi R. New insights into stages of Lyme disease symptoms from a novel hospital-based registry. Journal of Primary Care and Community Health. 2014;5(4):284-287.

Maloney EL. Controversies in Persistent (Chronic) Lyme Disease. J Infus Nurs. 2016 Nov; 39(6): 369–375. doi:10.1097/NAN.0000000000000195.

Rebman AW, Bechtold KT, Yang T, et al. The clinical, symptom, and quality-of-life characterization of a well-defined group of patients with posttreatment Lyme disease syndrome. Frontiers in Medicine (Lausanne). 2017 Dec 14;4:224.

Zhang Y. Persisters, persistent infections and the Yin–Yang model. Emerging Microbes & Infections. 2014 Jan 8;3:e3. doi:10.1038/emi.2014.3